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KMID : 0352720110350030360
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Journal of Ginseng Research
2011 Volume.35 No. 3 p.360 ~ p.367
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Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing
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Kim Young-Soo
Cho Ik-Hyun
Jeong Moon-Jin
Jeong Soon-Jeong
Nah Seung-Yeol
Cho Young-Sik
Kim Seung-Hyun
Go A-Ra
Kim Se-Eun
Kang Seong-Soo
Moon Chang-Jong
Kim Jong-Choon
Kim Sung-Ho
Bae Chun-Sik
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Abstract
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In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using
histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area and contracture measurements, keratinocyte migration rate, and calculation of infiltrating inflammatory cells. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds.
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KEYWORD
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Panax ginseng, Skin wound healing, Total ginseng saponin, Mice,
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